Funding j a has received support from nih grants dp1gm114862 r01ey028027 r01ey29799 and r01ey031039 john templeton foundation grant 60763 the uva strategic investment fund dupont guerry iii professorship and a gift from e w tullis n k is supported by the nih r01ai148741 r00ey024336 and r21ey030651.

A stress granule protein ddx3x which is involved in both nlrp3 inflammasome and stress granules assembly regulates nlrp3 inflammasome thereby constituting a critical checkpoint in stressed.

G western blot for mettl3 mettl14 ddx3x dicer1 and actin in molm 13 cells treated with 10 5 and 1 mu m of stm2457 or vehicle dmso for 72 h n 3 two tailed student rsquo s t test n s not.